Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice
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چکیده
منابع مشابه
Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice.
T helper 1 cells play a major role in protective immunity against mycobacterial pathogens. Since the antigen (Ag) specificity of CD4(+) human T cells is strongly controlled by HLA class II polymorphism, the immunogenic potential of candidate Ags needs to be defined in the context of HLA polymorphism. We have taken advantage of class II-deficient (Ab0) mice, transgenic for either HLA-DRA/B1*0301...
متن کاملAssociation between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City
Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...
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CD8+ T cells are thought to play an important role in protective immunity to tuberculosis. The major histocompatibility complex class I subtype HLA-A*0201 is one of the most prevalent class I alleles, with a frequency of over 30% in most populations. HLA-A*0201 transgenic, H-2Db/mouse beta2-microglobulin double-knockout mice (HHD) which express human HLA-A*0201 but no mouse class I, was shown t...
متن کاملHLA class II transgenic mice: the chance to unravel the basis of HLA class II associations with disease
T hough the first association between HLA and disease was established with an HLA class I molecule (1), the majority of HLA-disease associations have been with HLA dass II molecules (2). Despite the awareness of such associations for nearly two decades, the pathophysiological role of HLA class II molecules in conferring susceptibility to the associated diseases remains poorly understood. One im...
متن کاملassociation between hla-class i and hla-class ii alleles and mycobacterium tuberculosis infection in iraqi patients from baghdad city
background: pulmonary tuberculosis (pt) is one of the endemic diseases in iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (hla) system. we sought to investigate the association between hla-class i (a and b) and -class ii (dr and dq) alleles in a sample of pt iraqi patients. methods: lymphocytes of 105 pt patients and 40 controls were phenotyped for ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.18.10797